蓝光如何通过加速褪黑激素分泌来减少夜间褪黑激素水平,从而改善睡眠质量?
蓝光通过加速褪黑激素分泌来减少夜间褪黑激素水平,从而改善睡眠质量的机制涉及多个方面。首先,蓝光对人体的影响主要是通过其短波长范围(446-466 nm)发挥作用,这一范围内的光被称为蓝光,它能够直接影响人类的褪黑激素分泌[2]。研究表明,蓝光能够抑制褪黑激素的产生,这种抑制作用与光的强度有关,即随着蓝光照射强度的增加,对褪黑激素分泌的抑制作用也会增强[2]。
此外,蓝光还能通过非成像视觉光感受器(non-image-forming photoreceptors),即含有视紫红质(melanopsin)的视网膜神经节细胞(retinal ganglion cells, RGCs),来调节人体的昼夜节律[16][18]。这些细胞不仅参与视觉功能,还负责将光信号传递到下丘脑中的视交叉上核(suprachiasmatic nucleus, SCN),从而调节人体的生物钟和其他非成像视觉功能,如褪黑激素的分泌[18]。
蓝光的这种作用对于改善睡眠质量具有重要意义。在夜间或白天接触蓝光时,可以通过抑制褪黑激素的分泌来提前调节人体的生物钟,使得在夜间更容易入睡,并且在白天保持清醒和警觉[2][12]。这对于那些生活在现代社会中的人们来说尤其重要,因为他们经常需要在不同的时间段进行工作和休息,而蓝光提供了一种有效的方式来帮助调整他们的生物钟,以适应不同的生活节奏。
然而,值得注意的是,虽然蓝光可以改善睡眠质量,但过度暴露于蓝光下可能会带来一些负面影响,如影响眼睛健康[7]。因此,在利用蓝光改善睡眠质量的同时,也需要注意控制蓝光的暴露强度和时间,以避免可能的副作用。
总之,蓝光通过加速褪黑激素分泌来减少夜间褪黑激素水平,从而改善睡眠质量。这一过程涉及到蓝光对褪黑激素分泌的直接抑制作用,以及蓝光通过含有视紫红质的视网膜神经节细胞传递到下丘脑中的视交叉上核,进而调节人体的昼夜节律。尽管蓝光具有改善睡眠质量的潜力,但也需要注意合理控制蓝光的暴露,以保护眼睛健康。
相关事件
事件名称 | 事件时间 | 事件概述 | 类型 |
单色LED蓝色光照对健康人体昼夜节律的影响研究 | 2007年10月至2008年10月 | 研究观察了新型发光二极管蓝光对健康人昼夜节律的影响及其安全性。 | 科学研究 |
蓝光照射组褪黑素分泌曲线前移 | 未明确指出具体时间,但涉及的研究是在2007年10月至2008年10月的期间进行的。 | 在蓝光照射组中,褪黑素分泌曲线较基线有明显的前移,显示出对生物节律的积极影响。 | 科学发现 |
蓝光照射组与对照组比较结果 | 未明确指出具体时间,但涉及的研究是在2007年10月至2008年10月的期间进行的。 | 蓝光照射组在褪黑素分泌曲线的变化上与对照组相比存在显著性差异,表明蓝光对生物节律有积极影响。 | 科学研究结果 |
蓝光照射组受试者健康状况良好 | 未明确指出具体时间,但涉及的研究是在2007年10月至2008年10月的期间进行的。 | 所有受试者在接受蓝光照射后,眼底、体温、血压、心率及血皮质醇和甲状腺激素水平无明显变化,未出现不适症状。 | 健康评估 |
相关组织
组织名称 | 概述 | 类型 |
北京大学第三医院 | 在该医院的神经科临床试验病房完成了关于蓝光对健康人昼夜节律影响的研究。 | 医疗/研究机构 |
参考文献
1. A. Lewy, T. Wehr et al. “Light suppresses melatonin secretion in humans..” Science(1980).
2. K. West, M. Jablonski et al. “Blue light from light-emitting diodes elicits a dose-dependent suppression of melatonin in humans..” Journal of applied physiology (2011). 619-26 .
3. J. Horne, J. Donlon et al. “Green light attenuates melatonin output and sleepiness during sleep deprivation..” Sleep (1991). 233-40 .
4. Jesus Minguillon, M. A. Lopez-Gordo et al. “Blue lighting accelerates post-stress relaxation: Results of a preliminary study.” PLoS ONE (2017).
5. Deva Reign, N. Dailey et al. “0037 Blue Light Exposure Facilitates Cortical Neural Efficiency Exclusive of Melatonin Effects.” Sleep (2022).
6. S. Chellappa, R. Steiner et al. “Acute exposure to evening blue‐enriched light impacts on human sleep.” Journal of Sleep Research (2013).
7. G. Tosini, Ian Ferguson et al. “Effects of blue light on the circadian system and eye physiology.” Molecular Vision (2016). 61 - 72.
8. Holly Barilla, P. Gehrman et al. “0048 Effects of Blue Filtering Lenses on Sleep and melatonin Production in Good Sleepers.” Sleep (2019).
9. B. Faraut, T. Andrillon et al. “Daytime Exposure to Blue-Enriched Light Counters the Effects of Sleep Restriction on Cortisol, Testosterone, Alpha-Amylase and Executive Processes.” Frontiers in Neuroscience (2020).
10. G. Brainard, J. Hanifin et al. “Action Spectrum for Melatonin Regulation in Humans: Evidence for a Novel Circadian Photoreceptor.” Journal of Neuroscience(2001).
11. B. Bjorvatn, K. Stangenes et al. “Randomized placebo-controlled field study of the effects of bright light and melatonin in adaptation to night work..” Scandinavian Journal of Work, Environment and Health (2007). 204-14 .
12. 刘娜,张楠,文冰亭等.单色LED蓝色光照对健康人体昼夜节律的影响[J].中国组织工程研究与临床康复,2009,13(30):5923-5926.
13. N. Nagai, M. Ayaki et al. “Suppression of Blue Light at Night Ameliorates Metabolic Abnormalities by Controlling Circadian Rhythms..” Investigative Ophthalmology and Visual Science (2019). 3786-3793 .
14. J. Phipps-Nelson, J. Redman et al. “Daytime exposure to bright light, as compared to dim light, decreases sleepiness and improves psychomotor vigilance performance..” Sleep (2003). 695-700 .
15. Burkhart Kimberly and Phelps James R.. “AMBER LENSES TO BLOCK BLUE LIGHT AND IMPROVE SLEEP: A RANDOMIZED TRIAL.” Chronobiology International (2009). 1602 - 1612.
16. D. Berson, Felice A. Dunn et al. “Phototransduction by Retinal Ganglion Cells That Set the Circadian Clock.” Science(2002).
17. E. Sunde, Torhild T Pedersen et al. “Blue-Enriched White Light Improves Performance but Not Subjective Alertness and Circadian Adaptation During Three Consecutive Simulated Night Shifts.” Frontiers in Psychology (2020).
18. S. Hattar, H. Liao et al. “Melanopsin-Containing Retinal Ganglion Cells: Architecture, Projections, and Intrinsic Photosensitivity.” Science(2002).
19. Fan Wu, Shuo Wu et al. “Blue light insertion at night is involved in sleep and arousal-promoting response delays and depressive-like emotion in mice.” Bioscience Reports (2021).
20. F. Scheer, M. Hilton et al. “Adverse metabolic and cardiovascular consequences of circadian misalignment.” Proceedings of the National Academy of Sciences of the United States of America(2009).
21. Tahereh Tekieh, S. Lockley et al. “Modeling melanopsin‐mediated effects of light on circadian phase, melatonin suppression, and subjective sleepiness.” Journal of Pineal Research (2020).
22. T. Sletten, S. Ftouni et al. “Randomised controlled trial of the efficacy of a blue-enriched light intervention to improve alertness and performance in night shift workers.” Occupational and Environmental Medicine (2017). 792 - 801.
23. C. Nowozin, A. Wahnschaffe et al. “Applying Melanopic Lux to Measure Biological Light Effects on Melatonin Suppression and Subjective Sleepiness..” Current Alzheimer Research (2017). 1042-1052 .
24. M. Münch, F. Linhart et al. “Effects of prior light exposure on early evening performance, subjective sleepiness, and hormonal secretion..” Behavioral Neuroscience (2012). 196-203 .
25. Cristiano L. Guarana, Christopher M. Barnes et al. “The effects of blue-light filtration on sleep and work outcomes..” Journal of Applied Psychology (2020).
26. M. I. Silvani, R. Werder et al. “The influence of blue light on sleep, performance and wellbeing in young adults: A systematic review.” Frontiers in Physiology (2022).
27. M. Geerdink, Thijs J. Walbeek et al. “Short Blue Light Pulses (30 Min) in the Morning Support a Sleep-Advancing Protocol in a Home Setting.” Journal of Biological Rhythms (2016). 483 - 497.
28. J. Phipps-Nelson, J. Redman et al. “BLUE LIGHT Exposure Reduces Objective Measures of Sleepiness during Prolonged Nighttime Performance Testing.” Chronobiology International (2009). 891 - 912.
29. J. Horne, O. Ostberg. “A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms..” International journal of chronobiology(1976).
30. T. Roenneberg, A. Wirz-Justice et al. “Life between Clocks: Daily Temporal Patterns of Human Chronotypes.” Journal of Biological Rhythms(2003).